Publications

All publications: HERE

Publications 2001-2020

1.  PMID: 32187552

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.

Uzureau S, Lecordier L, Uzureau P, Hennig D, Graversen JH, Homblé F, Mfutu PE, Oliveira Arcolino F, Ramos AR, La Rovere RM, Luyten T, Vermeersch M, Tebabi P, Dieu M, Cuypers B, Deborggraeve S, Rabant M, Legendre C, Moestrup SK, Levtchenko E, Bultynck G, Erneux C, Pérez-Morga D, Pays E.Cell Rep. 2020 Mar 17;30(11):3821-3836.e13. doi: 10.1016/j.celrep.2020.02.064.PMID: 32187552 Free PMC article. 

2.  PMID: 28924146

APOLs with low pH dependence can kill all African trypanosomes.

Fontaine F, Lecordier L, Vanwalleghem G, Uzureau P, Van Reet N, Fontaine M, Tebabi P, Vanhollebeke B, Büscher P, Pérez-Morga D, Pays E.Nature Microbiol. 2017 Nov;2(11):1500-1506. doi: 10.1038/s41564-017-0034-1. Epub 2017 Sep 18.PMID: 28924146 Free PMC article. 

3.  PMID: 27685262

Specific Endocytosis Blockade of Trypanosoma cruzi Exposed to a Poly-LAcNAc Binding Lectin Suggests that Lectin-Sugar Interactions Participate to Receptor-Mediated Endocytosis.

Brosson S, Fontaine F, Vermeersch M, Perez-Morga D, Pays E, Bousbata S, Salmon D.PLoS One. 2016 Sep 29;11(9):e0163302. doi: 10.1371/journal.pone.0163302. eCollection 2016.PMID: 27685262 Free PMC article. 

4.  PMID: 27198486

Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells.

Uzureau S, Coquerelle C, Vermeiren C, Uzureau P, Van Acker A, Pilotte L, Monteyne D, Acolty V, Vanhollebeke B, Van den Eynde B, Pérez-Morga D, Moser M, Pays E.Eur J Immunol. 2016 Aug;46(8):1854-66. doi: 10.1002/eji.201546252. Epub 2016 Jun 8.PMID: 27198486 Free article. 

5.  PMID: 26307671

Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1.

Vanwalleghem G, Fontaine F, Lecordier L, Tebabi P, Klewe K, Nolan DP, Yamaryo-Botté Y, Botté C, Kremer A, Burkard GS, Rassow J, Roditi I, Pérez-Morga D, Pays E.Nature Commun. 2015 Aug 26;6:8078. doi: 10.1038/ncomms9078.PMID: 26307671 Free PMC article. 

6.  PMID: 25899052

Adaptation of Trypanosoma rhodesiense to hypohaptoglobinaemic serum requires transcription of the APOL1 resistance gene in a RNA polymerase I locus.

Lecordier L, Uzureau P, Tebabi P, Brauner J, Benghiat FS, Vanhollebeke B, Pays E.Mol Microbiol. 2015 Aug;97(3):397-407. doi: 10.1111/mmi.13036. Epub 2015 May 15.PMID: 25899052 Free article. 

7.  PMID: 25256834

Identification of Trypanosoma brucei components involved in trypanolysis by normal human serum.

Lecordier L, Uzureau P, Tebabi P, Pérez-Morga D, Nolan D, Schumann Burkard G, Roditi I, Pays E.Mol Microbiol. 2014 Nov;94(3):625-36. doi: 10.1111/mmi.12783. Epub 2014 Sep 25.PMID: 25256834 Free article.

8.  PMID: 24975321

The molecular arms race between African trypanosomes and humans.

Pays E, Vanhollebeke B, Uzureau P, Lecordier L, Pérez-Morga D.Nature Rev Microbiol. 2014 Aug;12(8):575-84. doi: 10.1038/nrmicro3298. Epub 2014 Jun 30.PMID: 24975321 Review. 

9.  PMID: 23965626

Mechanism of Trypanosoma brucei gambiense resistance to human serum.

Uzureau P, Uzureau S, Lecordier L, Fontaine F, Tebabi P, Homblé F, Grélard A, Zhendre V, Nolan DP, Lins L, Crowet JM, Pays A, Felu C, Poelvoorde P, Vanhollebeke B, Moestrup SK, Lyngsø J, Pedersen JS, Mottram JC, Dufourc EJ, Pérez-Morga D, Pays E.Nature. 2013 Sep 19;501(7467):430-4. doi: 10.1038/nature12516. Epub 2013 Aug 21.PMID: 23965626 

10.  PMID: 23104568

Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms.

Brasseur A, Rotureau B, Vermeersch M, Blisnick T, Salmon D, Bastin P, Pays E, Vanhamme L, Pérez-Morga D.Eukaryot Cell. 2013 Feb;12(2):168-81. doi: 10.1128/EC.00077-12. Epub 2012 Oct 26.PMID: 23104568 Free PMC article.

11.  PMID: 22700656

Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.

Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhommé F, Bachmaier S, Kador M, Gossmann J, Dias FB, De Muylder G, Uzureau P, Magez S, Moser M, De Baetselier P, Van Den Abbeele J, Beschin A, Boshart M, Pays E.Science. 2012 Jul 27;337(6093):463-6. doi: 10.1126/science.1222753. Epub 2012 Jun 14.PMID: 22700656 Free article. 

12.  PMID: 22340731

Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4-like subfamily.

Salmon D, Bachmaier S, Krumbholz C, Kador M, Gossmann JA, Uzureau P, Pays E, Boshart M.Mol Microbiol. 2012 Apr;84(2):225-42. doi: 10.1111/j.1365-2958.2012.08013.x. Epub 2012 Mar 6.PMID: 22340731 Free article. 

13.  PMID: 20647424

Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR.Science. 2010 Aug 13;329(5993):841-5. doi: 10.1126/science.1193032. Epub 2010 Jul 15.PMID: 20647424 Free PMC article. 

14.  PMID: 20581292

Cellular and molecular remodeling of the endocytic pathway during differentiation of Trypanosoma brucei bloodstream forms.

Vanhollebeke B, Uzureau P, Monteyne D, Pérez-Morga D, Pays E.Eukaryot Cell. 2010 Aug;9(8):1272-82. doi: 10.1128/EC.00076-10. Epub 2010 Jun 25.PMID: 20581292 Free PMC article. 

15.  PMID: 19997494

C-terminal mutants of apolipoprotein L-I efficiently kill both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.

Lecordier L, Vanhollebeke B, Poelvoorde P, Tebabi P, Paturiaux-Hanocq F, Andris F, Lins L, Pays E.PLoS Pathog. 2009 Dec;5(12):e1000685. doi: 10.1371/journal.ppat.1000685. Epub 2009 Dec 4.PMID: 19997494 Free PMC article. 

16.  PMID: 18451305

A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans.

Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E.Science. 2008 May 2;320(5876):677-81. doi: 10.1126/science.1156296.PMID: 18451305 Free article. 

17.  PMID: 17910690

Human serum lyses Trypanosoma brucei by triggering uncontrolled swelling of the parasite lysosome.

Vanhollebeke B, Lecordier L, Perez-Morga D, Amiguet-Vercher A, Pays E.J Eukaryot Microbiol. 2007 Sep-Oct;54(5):448-51. doi: 10.1111/j.1550-7408.2007.00285.x.PMID: 17910690 

18.  PMID: 17488917

Diagnostic potential of a conserved genomic rearrangement in the Trypanosoma brucei gambiense-specific TGSGP locus.

Felu C, Pasture J, Pays E, Pérez-Morga D.Am J Trop Med Hyg. 2007 May;76(5):922-9.PMID: 17488917

19.  PMID: 17360487

Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum.

Vanhollebeke B, Nielsen MJ, Watanabe Y, Truc P, Vanhamme L, Nakajima K, Moestrup SK, Pays E.Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4118-23. doi: 10.1073/pnas.0609902104. Epub 2007 Feb 26.PMID: 17360487 Free PMC article. 

20.  PMID: 16847577

The function of apolipoproteins L.

Vanhollebeke B, Pays E.Cell Mol Life Sci. 2006 Sep;63(17):1937-44. doi: 10.1007/s00018-006-6091-x.PMID: 16847577 Review. 

21.  PMID: 16710327

The trypanolytic factor of human serum.

Pays E, Vanhollebeke B, Vanhamme L, Paturiaux-Hanocq F, Nolan DP, Pérez-Morga D.Nature Rev Microbiol. 2006 Jun;4(6):477-86. doi: 10.1038/nrmicro1428.PMID: 16710327 Review.

22.  PMID: 16020735

Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.

Pérez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F, Nolan DP, Lins L, Homblé F, Vanhamme L, Tebabi P, Pays A, Poelvoorde P, Jacquet A, Brasseur R, Pays E.Science. 2005 Jul 15;309(5733):469-72. doi: 10.1126/science.1114566.PMID: 16020735 Free article. 

23.  PMID: 15288623

Antigenic variation in Trypanosoma brucei: facts, challenges and mysteries.

Pays E, Vanhamme L, Pérez-Morga D.Curr Opin Microbiol. 2004 Aug;7(4):369-74. doi: 10.1016/j.mib.2004.05.001.PMID: 15288623 Review. 

24.  PMID: 15009886

Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstream.

Amiguet-Vercher A, Pérez-Morga D, Pays A, Poelvoorde P, Van Xong H, Tebabi P, Vanhamme L, Pays E.Mol Microbiol. 2004 Mar;51(6):1577-88. doi: 10.1111/j.1365-2958.2003.03937.x.PMID: 15009886 Free article. 

25.  PMID: 14963487

A differential role for actin during the life cycle of Trypanosoma brucei.

García-Salcedo JA, Pérez-Morga D, Gijón P, Dilbeck V, Pays E, Nolan DP.EMBO J. 2004 Feb 25;23(4):780-9. doi: 10.1038/sj.emboj.7600094. Epub 2004 Feb 12.PMID: 14963487 Free PMC article.

26.  PMID: 14747153

Distribution of apolipoprotein L-I and trypanosome lytic activity among primate sera.

Poelvoorde P, Vanhamme L, Van Den Abbeele J, Switzer WM, Pays E.Mol Biochem Parasitol. 2004 Mar;134(1):155-7. doi: 10.1016/j.molbiopara.2003.11.006.PMID: 14747153 No abstract available. 

27.  PMID: 12621437

Apolipoprotein L-I is the trypanosome lytic factor of human serum.

Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, Van Den Abbeele J, Pays A, Tebabi P, Van Xong H, Jacquet A, Moguilevsky N, Dieu M, Kane JP, De Baetselier P, Brasseur R, Pays E.Nature. 2003 Mar 6;422(6927):83-7. doi: 10.1038/nature01461.PMID: 12621437

28.  PMID: 12518862

The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense.

Radwanska M, Chamekh M, Vanhamme L, Claes F, Magez S, Magnus E, de Baetselier P, Büscher P, Pays E.Am J Trop Med Hyg. 2002 Dec;67(6):684-90. doi: 10.4269/ajtmh.2002.67.684.PMID: 12518862 

29.  PMID: 12408669

Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense.

Radwanska M, Claes F, Magez S, Magnus E, Perez-Morga D, Pays E, Büscher P.Am J Trop Med Hyg. 2002 Sep;67(3):289-95. doi: 10.4269/ajtmh.2002.67.289.PMID: 12408669 

30.  PMID: 12095111

Organization of telomeres during the cell and life cycles of Trypanosoma brucei.

Pérez-Morga D, Amiguet-Vercher A, Vermijlen D, Pays E.J Eukaryot Microbiol. 2001 Mar-Apr;48(2):221-6. doi: 10.1111/j.1550-7408.2001.tb00306.x.PMID: 12095111 

31.  PMID: 11254961

A receptor-like flagellar pocket glycoprotein specific to Trypanosoma brucei gambiense.

Berberof M, Pérez-Morga D, Pays E.Mol Biochem Parasitol. 2001 Mar;113(1):127-38. doi: 10.1016/s0166-6851(01)00208-0.PMID: 11254961